Interspecific Introgressive Origin of Genomic Diversity in the House Mouse

Interspecific Introgressive Origin of Genomic Diversity in the House Mouse
Kevin J. Liu, Ying Song, Michael H. Kohn, Luay Nakhleh
(Submitted on 22 Nov 2013)

We report on a genome-wide scan for introgression in a eukaryote. The scan identified kilobase-to-megabase-long regions of introgressive origin involving Mus spretus in six Mus musculus domesticus chromosomes, based on genomes sampled from and near the European range of sympatry. Our analyses point to the introgression of both adaptive driver and linked passenger loci. Introgression could transfer traits, such as the discovered warfarin resistance in European M. m. domesticus, and could create new traits, as we infer using a functional network analysis. Our study sheds new light on the extent of adaptive introgession and calls for new analyses of eukaryotic genomes that explicitly account for the possibility of introgression.

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