The most viewed preprints on Haldane’s Sieve in March 2014 were (note that there are six rather than the usual five because two posts had the exact same number of views at the time of this writing):
- Towards a new history and geography of human genes informed by ancient DNA. Pickrell and Reich argue that evidence from ancient DNA motivates a re-evaluation of many aspects of human population genetics.
- Alignathon: A competitive assessment of whole genome alignment methods. Earl et al. present a benchmarked comparison of several algorithms for multiple sequence alignment.
- LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies. Bulik-Sullivan et al. present a method for distinguishing between different models that lead to genome-wide inflation of test statistics in GWAS.
- Conditions for the validity of SNP-based heritability estimation. Lee and Chow present an analysis of the assumptions underlying a popular method for estimating heritability using distantly related individuals.
- High burden of private mutations due to explosive human population growth and purifying selection. Gao and Keinan show an effect of recent population growth in humans on the allele frequency spectrum.
- Author post: Genetic influences on translation in yeast. Albert and Kruglyak discuss their preprint (with co-authors) comparing genetic variation in mRNA levels with genetic variation in protein levels in a yeast cross.