The most viewed preprints on Haldane’s Sieve this month were:

• Our Paper: Genome-wide inference of ancestral recombination graphs. Adam Siepel’s post on his preprint with Matthew Rasmussen describing a new method for inferring ancestral recombination graphs repeated as the most viewed post this month, and is now the most viewed post IN THE HISTORY OF THE WORLD*.
• Sailfish: Alignment-free Isoform Quantification from RNA-seq Reads using Lightweight Algorithms. Patro et al. present a novel algorithm for quantifying gene expression using RNA-seq that avoids the computationally expensive step of read alignment.
• The Population Genetic Signature of Polygenic Local Adaptation. Berg and Coop present a method for detecting selection on complex phenotypes by using loci identified in genome-wide association studies.
• A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers. Smith et al. develop a test for selection on enhancers that combines comparative genomic data with data from saturation mutagenesis experiments.
• Our Paper: The genomic impacts of drift and selection for hybrid performance in maize. Jeff Ross-Ibarra describes his work with colleagues (Gerke et al.) tracking allele frequency changes in maize over multiple rounds of selection for hybrid performance.

*”The world” is defined for these purposes as Haldane’s Sieve.