The most viewed preprints on Haldane’s Sieve in January 2013 were:

• Our paper: Assemblathon 2 and pizza. Keith Bradnam discusses the analogies between pizza making and genome assembly in an “Our paper” post on Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species.
• Our paper: Epistasis not needed to explain low dN/dS. Joshua Plotkin discusses his group’s preprint Epistasis not needed to explain low dN/dS, which is a response to a paper by Breen et al. on the prevalence of epistasis in protein sequence evolution.
• Our paper: A statistical framework for joint eQTL analysis in multiple tissues. Tim Flutre and William Wen discuss their preprint on eQTL mapping.
• Thoughts on: Polygenic modeling with Bayesian sparse linear mixed models. Alkes Price comments on a preprint by Zhou et al. on heritability estimation and phenotype prediction from dense genotype data.
• Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution. Chandler et al. review the influence of genetic background on the phenotypic effects of mutations.