The most viewed preprints on Haldane’s Sieve in March 2013 were:
- RNA-Seq Mapping Errors When Using Incomplete Reference Transcriptomes of Vertebrates. Pyrkosz et al. evaluate the performance of RNA-seq to measure gene expression in organisms where the database of reference transcripts is incomplete. An “Our paper” post is here, and see the discussion on Titus Brown’s blog.
- Genomic evidence of rapid and stable adaptive oscillations over seasonal time scales in Drosophila. Bergland et al. sequence wild Drosophila populations at various times over several years, and provide provide evidence for hundreds of loci under temporally-varying selection.
- Soft selective sweeps are the primary mode of recent adaptation in Drosophila melanogaster. Garud et al. develop a population genetic method to search for the genetic signature of “soft” selective sweeps, and argue that such sweeps are widespread. An “Our paper” post is here.
- Sensitive Long-Indel-Aware Alignment of Sequencing Reads. Marschall and Schönhuth present a new alignment algorithm for short read data.
- Genomic Sequence Diversity and Population Structure of Saccharomyces cerevisiae Assessed by RAD-seq. Cromie et al. perform a large-scale analysis of genetic diversity in yeast populations.