Below are the most viewed posts on Haldane’s Sieve in April 2013. We’ve listed six instead of our usual five posts because the last two posts had identical numbers of views at the time of writing.

• Our paper: The causal meaning of Fisher’s average effect. James Lee discusses the story behind his paper clarifying RA Fisher’s presentation of the fundamental theorem of natural selection.
• Our paper: Improving transcriptome assembly through error correction of high-throughput sequence reads. Matt MacManes discusses his paper on de novo transcriptome assembly.
• Genomic evidence of rapid and stable adaptive oscillations over seasonal time scales in Drosophila. This preprint from Bergland et al. on seasonal variation in selective pressure in Drosophila was also one of the most viewed preprints last month.
• Timing of ancient human Y lineage depends on the mutation rate: A comment on Mendez et al. Melissa Wilson Sayres comments on a recent paper describing a new basal lineage of the human Y chromosome genealogy.
• Thoughts on: Loss and Recovery of Genetic Diversity in Adapting Populations of HIV. An exchange between Richard Neher and the authors of a preprint on the population genetics of HIV.
• Our paper: The effects of transcription factor competition on gene regulation. Radu Zabet describes two preprints on applications of a stochastic model for transcription factor binding.