The waiting time for a second mutation: an alternative to the Moran model
Rinaldo B. Schinazi
(Submitted on 28 Jun 2013)

The appearance of cancer in a tissue is thought to be the result of two or more successive mutations. We propose a stochastic model that allows for an exact computation of the distribution of the waiting time for a second mutation. This models the time of appearance of the first cancerous cell in a tissue. Our model is an alternative to the Moran model with mutations.