The most viewed preprints on Haldane’s Sieve this month were:

• Our Paper: Genome-wide inference of ancestral recombination graphs. Adam Siepel’s post on his preprint with Matthew Rasmussen describing a new method for inferring ancestral recombination graphs is the most viewed post for the third month in a row.
• Author post: The identifiability of piecewise demographic models from the sample frequency spectrum. Bhaskar and Song describe their preprint showing that some classes of demographic histories are indeed identifiable from the allele frequency spectrum alone. Graham Coop provides some context in this post.
• Author post: The Population Genetic Signature of Polygenic Local Adaptation. Berg and Coop discuss their preprint on testing for polygenic adaptation using alleles identified in genome-wide association studies.
• Biological Averaging in RNA-Seq. Biswas et al. propose that pooling samples in RNA-seq experiments is a cost-effective alternative to sequencing individual samples.
• Our paper: An integrative genomic approach illuminates the causes and consequences of genetic background effects. Chris Chandler describes his work with colleagues (Chandler et al.) exploring the causes of variation in the effects of a mutation in different genetic backgrounds.