The most viewed posts on Haldane’s Sieve last month were:
- Hierarchical Bayesian model of population structure reveals convergent adaptation to high altitude in human populations. Foll et al. describe a new model for identifying convergent adaptation in different populations of a species, and apply the model to identifying genetic adaptations to altitude in humans. The authors describe their paper here.
- Cell specific eQTL analysis without sorting cells. Westra et al. describe an approach to separate expression measurements from heterogeneous blood samples into expression measurements for individual cell types, and identify genetic variants associated with cell-type specific expression.
- Author post: Genome scans for detecting footprints of local adaptation using a Bayesian factor model. Duforet-Frebourg et al. describe their preprint on a new model for detecting local adaptation at the genetic level.
- No evidence that natural selection has been less effective at removing deleterious mutations in Europeans than in West Africans. Do et al. show that there has been no difference in the rate of accumulation of deleterious alleles between European and west African populations, but that the archaic Denisovan population does show evidence of such an accumulation.
- Extensive epistasis within the MHC contributes to the genetic architecture of celiac disease. Goudey et al. show that epistatic interactions between loci in the major histocompatibility complex influence risk of celiac disease.