Identifying recombination hotspots using population genetic data

Identifying recombination hotspots using population genetic data
Adam Auton, Simon Myers, Gil McVean
(Submitted on 17 Mar 2014)

Motivation: Recombination rates vary considerably at the fine scale within mammalian genomes, with the majority of recombination occurring within hotspots of ~2 kb in width. We present a method for inferring the location of recombination hotspots from patterns of linkage disequilibrium within samples of population genetic data. Results: Using simulations, we show that our method has hotspot detection power of approximately 50-60%, but depending on the magnitude of the hotspot. The false positive rate is between 0.24 and 0.56 false positives per Mb for data typical of humans. Availability: this http URL

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