This month set a new record for traffic to Haldane’s Sieve; thanks to everyone for the support. The most viewed posts were:
- Author post: Probabilities of Fitness Consequences for Point Mutations Across the Human Genome. Adam Siepel discusses his paper (with co-authors) Gulko et al., which describes a new statistical method for identifying important non-coding elements in the human genome.
- Cross-population Meta-analysis of eQTLs: Fine Mapping and Functional Study. Wen et al. describe a new approach to identifying genetic variants that influence gene expression by combining evidence across populations. An author post is here.
- Author post: Century-scale methylome stability in a recently diverged Arabidopsis thaliana lineage. Becker et al. discuss their preprint showing that methylation patterns in Arabidopsis are stable across diverse environmental conditions.
- The genetic ancestry of African, Latino, and European Americans across the United States. Bryc et al. document regional differences in ancestry across the United States in the 23andMe database.
- Non-crossover gene conversions show strong GC bias and unexpected clustering in humans. Williams et al. discuss the first genome-wide study of gene conversion events, and show that these events tend to cluster in the genome.