The most viewed posts on Haldane’s Sieve this month were:
- Author post: Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance. Pleuni Pennings describes her paper (with co-authors) on the evolution of drug resistance in infectious disease.
- Massive migration from the steppe is a source for Indo-European languages in Europe. Haak et el. present a large study of ancient DNA in Europe, and show that a post-Neolithic migration from the steppe has had a dramatic impact on the population structure of Europe today.
- Thoughts on: Probabilities of Fitness Consequences for Point Mutations Across the Human Genome. This post by Greg Cooper and colleagues was one of the most viewed posts last month as well. Adam Siepel’s initial post on this paper was also highly viewed this month.
- Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes. Lipson et al. propose a new method for estimating mutation rates, and apply the method to humans.
Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations
Haber et al. present an analysis of the population genetic history of Armenian populations.