Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data
Jean-Philippe Fortin , Kasper D Hansen
Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can be reliably estimated using epigenetic data from two different platforms, the Illumina 450k DNA methylation microarray and DNase hypersensitivity sequencing. We do this by exploiting the fact that the structure of long range correlations differs between open and closed compartments. This work makes A/B compartments readily available in a wide variety of cell types, including many human cancers.