Genomics has recently celebrated reaching the \$1000 genome milestone, making affordable DNA sequencing a reality. This goal of the sequencing revolution has been successfully completed. Looking forward, the next goal of the revolution can be ushered in by the advent of sequencing sensors – miniaturized sequencing devices that are manufactured for real time applications and deployed in large quantities at low costs. The first part of this manuscript envisions applications that will benefit from moving the sequencers to the samples in a range of domains. In the second part, the manuscript outlines the critical barriers that need to be addressed in order to reach the goal of ubiquitous sequencing sensors.