TreeQTL: hierarchical error control for eQTL findings
Christine Peterson, Marina Bogomolov, Yoav Benjamini, Chiara Sabatti
Commonly used multiplicity adjustments fail to control the error rate for reported findings in many expression quantitative trait loci (eQTL) studies. TreeQTL implements a stage-wise multiple testing procedure which allows control of appropriate error rates defined relative to a hierarchical grouping of the eQTL hypotheses. The R package TreeQTL is available for download at http://bioinformatics.org/treeqtl.