TreeQTL: hierarchical error control for eQTL findings

TreeQTL: hierarchical error control for eQTL findings

Christine Peterson, Marina Bogomolov, Yoav Benjamini, Chiara Sabatti
doi: http://dx.doi.org/10.1101/021170

Commonly used multiplicity adjustments fail to control the error rate for reported findings in many expression quantitative trait loci (eQTL) studies. TreeQTL implements a stage-wise multiple testing procedure which allows control of appropriate error rates defined relative to a hierarchical grouping of the eQTL hypotheses. The R package TreeQTL is available for download at http://bioinformatics.org/treeqtl.

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