The most viewed posts on Haldane’s Sieve in November 2013 were:
- The evolution of sex differences in disease genetics. Gilks et al. review quantitative and evolutionary genetics results on the evolution of sex-specific genetic architectures underlying traits.
- Reducing pervasive false positive identical-by-descent segments detected by large-scale pedigree analysis. Durand et al. use a large genomic dataset from the personal genetics company 23andMe to calibrate false positive rates in analysis of genomic regions identified as identical-by-descent, and introduce a method to reduce false positives.
- Data Mining of Online Genealogy Datasets for Revealing Lifespan Patterns in Human Population. Fire and Elovici use online genealogy databases to estimate the heritability of human lifespan. Note that Yaniv Erlich suggests this study is in violation of the terms of service of the database used.
- The Functional Consequences of Variation in Transcription Factor Binding. The comment thread on the Cusanovich et al. preprint (which was the most viewed preprint last month) continued this month with comments from Casey Brown.
- Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Pickrell presents a method for choosing the types of functional genomic data that are relevant for a given trait, and applies the method to genome-wide association studies of 18 traits.
Haldane's Sieve 