Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population

Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population

Sujatha Jagannathan, Robert K. Bradley

An Extended Maximum Likelihood Inference of Geographic Range Evolution by Dispersal, Local Extinction and Cladogenesis

An Extended Maximum Likelihood Inference of Geographic Range Evolution by Dispersal, Local Extinction and Cladogenesis

Champak Beeravolu Reddy, Fabien Condamine

Evolutionary dynamics of selfish DNA generates pseudo-linguistic features of genomes

Evolutionary dynamics of selfish DNA generates pseudo-linguistic features of genomes
Michael Sheinman, Anna Ramisch, Florian Massip, Peter F. Arndt
(Submitted on 4 Feb 2016)

Since the sequencing of large genomes, many statistical features of their sequences have been found. One intriguing feature is that certain subsequences are much more abundant than others. In fact, abundances of subsequences of a given length are distributed with a scale-free power-law tail, resembling properties of human texts, such as the Zipf’s law. Despite recent efforts, the understanding of this phenomenon is still lacking. Here we find that selfish DNA elements, such as those belonging to the Alu family of repeats, dominate the power-law tail. Interestingly, for the Alu elements the power-law exponent increases with the length of the considered subsequences. Motivated by these observations, we develop a model of selfish DNA expansion. The predictions of this model qualitatively and quantitatively agree with the empirical observations. This allows us to estimate parameters for the process of selfish DNA spreading in a genome during its evolution. The obtained results shed light on how evolution of selfish DNA elements shapes non-trivial statistical properties of genomes.

PoPoolationTE2: comparative population genomics of transposable elements using Pool-Seq

PoPoolationTE2: comparative population genomics of transposable elements using Pool-Seq

Robert Kofler, Daniel Gomez-Sanchez, Christian Schloetterer

Fine-scale human population structure in southern Africa reflects ecological boundaries

Fine-scale human population structure in southern Africa reflects ecological boundaries

Caitlin Uren, Minju Kim, Alicia R Martin, Dean Bobo, Christopher R Gignoux, Paul D van Helden, Marlo Moller, Eileen G Hoal, Brenna M Henn

The stasis that wasn’t: Adaptive evolution goes against phenotypic selection in a wild rodent population

The stasis that wasn’t: Adaptive evolution goes against phenotypic selection in a wild rodent population

Timothée Bonnet, Peter Wandeler, Glauco Camenisch, Erik Postma

Bayesian Node Dating based on Probabilities of Fossil Sampling Supports Trans-Atlantic Dispersal of Cichlid Fishes

Bayesian Node Dating based on Probabilities of Fossil Sampling Supports Trans-Atlantic Dispersal of Cichlid Fishes

Michael Matschiner, Zuzana Musilová, Julia M I Barth, Zuzana Starostová, Walter Salzburger, Mike Steel, Remco Bouckaert